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This oxidative crisis leads to red blood cell destruction, a key concern in malaria treatment and CSIR NET life sciences exams. Primaquine Mechanism in Hemolysis Primaquine treats Plasmodium vivax relapses but its quinone metabolites like 5,6-POQ generate ROS, oxidizing hemoglobin and GSH

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10.1007/s00431-002-1128-0 102

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Furthermore, the inhibition of oxidative stress by apigenin in vitro has demonstrated the activation of Nrf2, HO-1, SOD, and CAT activities