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Both medications are FDA-approved for chronic weight management in adults with obesity or overweight with associated health conditions, but they work differently and produce varying results

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When you combine drugs that have similar side effects, including fatigue and mood changes, these side effects tend to be more intense than if you took each drug on its own

The usual frequency for intramuscular doses of B12 shots is every 10 days, followed by maintenance doses at varying intervals

PMID 12397271