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Valproate should not be administered to a woman of childbearing potential unless other medications have failed to provide adequate symptom control or are otherwise unacceptable [seeWarnings and Precautions (5.2, 5.3, 5.4), Use in Specific Populations (8.1), andPatient Counseling Information (17)]

Mendelian randomization evidence indicates that elevated KYN levels have a causal relationship with increased risk of depression, with each standard deviation increase in KYN corresponding to ~ 1.4-fold higher odds of developing depression [50]

Diebold J et al

The potential number of peptides is enormous, but of those enormous numbers, very few of them have actual benefits, he added