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The upstream segment focuses on the procurement of raw materials, specifically the three constituent amino acids: L-Glutamic acid, L-Cysteine, and Glycine

2.1.6 Connective tissue growth factor Connective tissue growth factor (CTGF) is an immediate early protein regulated by transforming growth factor-beta (TGF-) and it plays a crucial role in the proliferation of fibroblasts and the production of the extracellular matrix (ECM) (8284)

Drug, Healthcare and Patient Safety 13:8194 Torres J, Bonovas S, Doherty G, Kucharzik T, Gisbert JP, Raine T, Adamina M, Armuzzi A, Bachmann O, Bager P (2020) ECCO guidelines on therapeutics in Crohns disease: medical treatment

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We observed no significant changes in the expression of p53 or p21 in keloid lesions or fibroblasts compared to those in normal skin