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Tirzepatide represents a dual-action GLP-1 and GIP receptor agonist that requires careful dose escalation to achieve optimal weight loss and metabolic outcomes
Increased delivery of bile acids to distal gut following gastric bypass, and hence their increased stimulation of TGR5 receptors present on enteroendocrine cells in the distal gut, are correlated with the elevated levels of GLP-1 and improvement of glucose tolerance (Hage et al., Other important results of the present study demonstrate that TGR5-induced release of GLP-1 and PYY from enteroendocrine cells is modulated by endogenous agents produced within the wall of the gut such as H 2 S (Linden et al., 2011
Most patients start at a low dose once weekly for at least four weeks
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