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Moreover, at an APAP dose of 400 mg/kg, hepsin / mice experienced rapid mortality within 8 to 10 h

doi: 10.1016/j.exer.2018.02.002 92

The charged nature of GSH (negative at physiological pH) suggests that GSH cannot passively diffuse into the mitochondria, because the mitochondrial matrix has a negative potential relative to the cytoplasm

Nanosuspensions and Polymeric Nanoparticles The rationale for using nanosuspensions lies in their ability to increase the surface area of poorly soluble drugs, thereby enhancing dissolution velocity

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