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Efficacy and safety of sitagliptin versus glipizide in patients with type 2 diabetes and moderate-to-severe chronic renal insufficiency

Main topics are carbonylated and glutathionylated proteins as well as modification of selected amino acids (Cys,

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This distinction affects their roles: The primary neurotransmitter in the central nervous system is glutamate while glutamine serves as an essential nitrogen source for protein synthesis and other metabolic pathways

However, the review stresses that direct attribution of these effects to GLP-1R-mediated anti-inflammatory pathways remains to be conclusively demonstrated