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Inflammatory & Nitric Oxide Pathways Investigated for potential modulation of inflammatory signaling and NO-related mechanisms in preclinical models of inflammation and stress

Ballard and colleagues (Growth Regulation, 1993) reported that IGF-I binds IGFBP-3 with roughly one thousand times the affinity of LR3IGF-I, and Wilson and colleagues (2000) found that, unlike IGF-I, the Long R3 variant did not raise serum IGFBP-3 in adolescent monkeys

Studies also confirmed procollegagen synthesis to be increased by almost 70% in dermal fibroblasts

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