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The standard schedule begins at 0.3 mg weekly for four weeks, then escalates to 0.6 mg for four weeks, followed by 1.2 mg for four weeks, then 1.8 mg for four weeks, ultimately reaching the maintenance dose of 2.4 mg weekly

Nevertheless, the selective targeting of neutrophils using high-affinity ligands presents a challenge because of their close lineage similarity to other myeloid cells (89)

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This can be exacerbated by high toxin levels