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Adjacent signaling nodes (ERK/MAPK and PI3K/AKT)
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Co-administration could lead to excessive down-regulation of mTORC1, potentially blunting necessary cellular repair, immune function, and wound healing
57 While the increase of free IGF-2 is associated with the suppression of insulin, IGF-1, and GH serum concentration, 58 the binding of IGF-2 to IGFBPs prevents excessive free IGF-2 in serum to cause hypoglycemia
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