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Acknowledgements This study has been delivered through the NIHR Manchester Biomedical Research Centre (BRC) (NIHR203308)
Overall, the review highlights metabolism as a key determinant of GBM pathophysiology and a promising target for therapeutic innovation, emphasizing the importance of continued translational research to identify and exploit context-specific metabolic vulnerabilities in this highly lethal disease
Understanding variants in GIPR and FTO, and MC4R can support a more informed conversation with your healthcare provider about whether low-dose semaglutide is likely to be effective or if different dosing strategies may be warranted for your genetic profile
Nutritional deficiencies: Changes in appetite, nausea, or rapid weight loss can lead to low levels of calcium, vitamin D, and other nutrients that support strong teeth and bones
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