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P = 0.036), as estimated from linear mixed models on log-transformed AUC values (Figures 6C, D)

104 These indicate that cAMP is regulated via PDEs, and two direct downstream effectors of cAMP (PKA and Epac)

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Finally, agonist-induced internalization and recycling of a green fluorescent protein (GFP)-tagged human GLP-1R construct expressed in HEK 293 cells was visualized using confocal microscopy (Fig