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A key limitation: metformin's benefit in the DPP was attenuated in participants aged 60 and older, where the number needed to treat rose substantially

Conversely, those who have recently gained weight due to life events like the pandemic, family matters, or lifestyle changes might benefit from temporary medication assistance to revert to healthier habits

This finding matches with the observation that most patients suffering from fructose malabsorption have no unpleasant intestinal effects when consuming sucrose

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