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Bimagrumab to improve recovery after hip fracture in older adults: a multicentre, double-blind, randomised, parallel-group, placebo-controlled, phase 2a/b trial
Interestingly, FGF21, SREBP-1c, and FAS mRNA in the liver tissues of the model group of mice and protein expression was increased compared with the control group, while liver kinase B1 (LKB1) mRNA expression was reduced
But the exact mechanism by which this therapeutic effect sometimes becomes a pathological one, where delayed emptying crosses the line into permanent gastroparesis, remains unclear
However, more evidence is needed to clarify their systemic effects and controversial direct hepatic benefits
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