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Next, we examined whether reduced HGP in Dpp4 hep/ mice is mediated by DPP4s action on GLP-1 receptor (GLP-1R) signaling

A critical and unresolved translational question is whether the 0.4% CSF-to-plasma ratio achieved at clinical doses is sufficient to meaningfully engage central GLP-1 receptors and activate the neuroprotective pathways described in Section 5

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For one or two months out of every three they are too exhausted to function

Andrew: Earlier, you mentioned a patient, or maybe it was patients, plural, that experienced a more rapid transition out of a COVID infection or maybe more recovery from long COVID symptoms, et cetera