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doi:10.1101/2020.10.02.20202614 73
Clinical Studies The first clinical, pilot study on antioxidants, showed an improvement of GO soft tissue involvement in patients treated with an antioxidant mixture containing allopurinol plus nicotinamide, compared with those given placebo (54)
Product Highlights Each vial contains 10 mL solution (~100 sprays) Each spray delivers 0.1 mL = 100 mcg Melanotan II Total MT-2 Content: 10 mg per vial Specialized pharmaceutical-grade nasal solution designed for comfort and ease on the nose Unlike many other nasal sprays on the market, this formula avoids irritation and dryness Packaged in Class A, lead-free pharmaceutical glass bottles Tamper/Child-Proof Cap + Orifice Reducer for integrity, sterility, and ease of use Benefits Skin pigmentation studied for stimulating melanin production leading to tanning effects Libido enhancement explored for central melanocortin receptor activation linked to arousal Photoprotection research interest in UV protection through melanin increase Energy and appetite melanocortin pathways tied to appetite and metabolic regulation Sexual health investigated alongside PT-141 for overlapping melanocortin activity Localized Effects with Nasal Spray Rapid uptake through the nasal mucosa Direct access to central nervous system pathways linked to melanocortin activity Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness What Researchers Use It For Mechanism: binds melanocortin receptors (MC1R, MC3R, MC4R, MC5R) Tanning and pigmentation effects studied in humans and animals Explored in erectile dysfunction and libido studies Investigations into photoprotection and metabolic roles Identity & Specs Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-Pro-Val-NH2 Formula / M.W.: C50H69N15O9, ~1024 g/mol CAS: 121062-08-6 Form: Sterile nasal spray solution Net per vial: 10 mL (~100 sprays) Total Content: 10 mg Melanotan II per vial Purity: 99% (HPLC) Identity: MS-verified (per COA) Storage: Refrigerate 28 C, protect from light Selected Research PubChem entry chemical identity: Skin pigmentation and tanning studies: Photoprotection and melanin production: Melanocortin receptor activity review: Disclaimer This product is intended for laboratory research use only
Additionally, the activation of microglia and astrocytes in ALS leads to the production of ROS and pro-inflammatory cytokines, further exacerbating oxidative damage and motor neuron degeneration [170]
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