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The pathway is sometimes referred to as a cycle, but according to its classical representation, it is a linear sequence that links reduction of H 2 O 2 , catalysed by APX, to oxidation of NADH or NADPH, catalysed by MDHAR and GR (Fig
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GPX4 is an antioxidant enzyme that primarily reduces lipid peroxides, especially lipid hydroperoxides, into their corresponding alcohols, thus protecting cell membranes from oxidative damage [39]
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