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For example, the treatment with acetyl-l-carnitine induced haeme oxygenase enzyme in rat astrocytes in a dose- and time-dependent fashion, heat shock protein 60 upregulation, and increased expression of the nuclear factor erythroid 2-related factor 2 transcription factor, a master regulator of antioxidant proteins [18]

McCormick LM, Kydd AC, Dutka DP

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We typically recommend a 24 week break after 812 weeks on for chronic protocols the necessity isn't fully established, but it's a sensible conservative approach for long-term use

Shim et al., 2024)