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I have seen patients who are taking three glucose-lowering medications
The most effective therapy available now is Zepbound, which causes about 20% weight loss
PMID 18272931
The SELECT trial associated semaglutide with reduced major cardiovascular events in certain high-risk populations
Tirzepatide may cause slightly more headaches initially due to its dual receptor activation affecting both GLP-1 and GIP pathways in the brain simultaneously, though the data does not show a statistically significant difference between the two medications
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