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Peer review Peer review information Nature Reviews Cardiology thanks Stephen Bain and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
Initially identified as a secreted factor induced by exercise and cold exposure, METRNL promotes energy expenditure and improves glucose tolerance through mechanisms involving immuneadipose crosstalk and beige adipocyte activation (Rao et al., 2014)
Make sure you talk to your healthcare provider before taking berberine, especially if you take other medications
That matters because these symptoms rarely arrive alone
She said it was good to see the findings replicated in a separate database, from the National Institutes of Health s All of Us database, but would like to see more follow-up, because some other studies have not found a similar effect
