Semaglutide's weight-management evidence comes chiefly from the STEP program, published in The New England Journal of Medicine in 2021
Most people find nausea, diarrhea, and similar effects fade as they move through each dose level
Pancreas 14:290294 Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R, Matthews DR (2012) Management of hyperglycaemia in type 2 diabetes: a patient-centered approach
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You may still prescribe compounded GLP-1 drugs, but your prescription must clearly articulate a medically necessary significant difference from the commercially available drug product