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People taking newer GLP-1 drugs such as tirzepatide were 41% less likely to discontinue treatment than those using older medications such as liraglutide
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Not as an independent driver of weight loss the evidence for that is weak
Similar glycemic control in the 2 treatment groups was desired in order to not confound the interpretation of the retinal data
A 2025 Nature Medicine analysis of the SURMOUNT-1 trial showed that tirzepatide achieved similar 72-week weight reduction in carriers of pathogenic MC4R mutations (18.3%) and noncarriers (19.9%), suggesting preserved responsiveness in the most common form of monogenic obesity [137]
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