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Patients on longevity protocols benefit from the visceral fat reduction and metabolic improvement that semaglutide produces alongside their other interventions

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Finally, one can foresee a future where combination therapy becomes common: for example, a patient with diabetes and obesity might be on both a GLP-1 RA and an SGLT2 inhibitor (for complementary weight loss and cardio-renal protection, which is already done)

The mean (SD) absolute weight loss from the index date to the end of follow-up was 14.6 (9.9) kg in the semaglutide 2.4 mg cohort and 17.2 (11.7) kg in the tirzepatide cohort, which represented a mean (SD) percent weight loss of 14.1% (9.6) and 16.5% (10.8), respectively

Heres how the two formats compare and how to choose between them