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GLP-1 has also been reported to increase secretory granules docked at the plasma membrane and also increases the frequency of compound exocytosis (60)
We next examined the effect of mGIPR-Ab/GLP-1 on body weight using two previously characterized molecules of mGIPR-Ab/GLP-1 (mGIPR-Ab/P1 (ref
A strong submission includes your HbA1c trend (showing progression toward diabetes), BMI, family history of type 2 diabetes, failed prior interventions, and any cardiovascular risk factors
dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies
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