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Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

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Staresinic M., Japjec M., Vranes H., Prtoric A., Zizek H., Krezic I., Gojkovic S., Smoday I.M., Oroz K., Staresinic E., et al

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HGHs anabolic effects are mediated primarily through IGF-1, which then acts on peripheral tissues such as muscle and bone. Laron, Z., Pediatric Endocrinology Reviews IGF-1 LR3: Direct Muscle Growth Stimulator IGF-1 LR3 binds directly to IGF-1 receptors on muscle fibers, triggering: Muscle cell differentiation and proliferation Activation of satellite cells , essential for muscle repair and new muscle fiber growth Enhanced nutrient uptake (glucose, amino acids, creatine) Because of this direct action , IGF-1 LR3 can stimulate local muscle hypertrophy without relying on systemic conversion pathways