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The fit returned values for the initial hydride transfer of k 2 = 2,530 1,230 s 1 and k -2 = 12,374 2,486 s 1 followed by a slower net reduction of the flavin with rates of k 3 = 0.33 0.05 s 1 and k -3 = 1.3 0.1 s 1

doi: 10.1093/ecco-jcc/jjy004 5 AdolphTEMeyerMSchwrzlerJMayrLGrabherrFTilgH

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Important Cautions: Side Effects and Stopping the Drugs GLP-1 medications are effective but carry significant side effects, particularly during dose escalation

No FDA-approved generics exist for either tirzepatide or semaglutide as of April 2026