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Its important to see a doctor quickly if any of the following are true: There are signs of possible infection (such as redness, warmth, or a fever) Your leg is swollen and pale or unusually cool You have calf pain after a period of prolonged sitting You have swelling in both legs along with breathing problems Any serious pain develops suddenly While leg pain usually isnt a medical emergency, you should seek immediate medical attention if any of the following applies to your pain: Youre unable to walk or stand You develop pain, swelling, redness, or warmth in your calf You have a sudden injury with a deep cut or exposed tissue You heard a pop or grinding sound when you injured your leg Medication Options Common over-the-counter medications to help relieve leg pain include acetaminophen and nonsteroidal anti-inflammatory medications (NSAIDs), such as aspirin or ibuprofen

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The date on which the opened vial will be considered expired should be calculated (up to 28 days after the vial opening) and mentioned on the label

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