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Low SAM, excessive methylation demand, impaired creatine synthesis, reduced glutathione availability and oxidative stress may place additional strain on mitochondria, potentially contributing to fatigue, variable cognitive stamina, sensory sensitivity, poor stress tolerance and slow recovery from illness
There is damage to the substantia nigra (pars compacta) and a decrease in dopamine production
Weight reduction can sometimes lead to small decreases in TSH levels and may reduce levothyroxine requirements in some patients with hypothyroidism
143(21):e984-1010
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