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Increased TMAO levels in addition to endothelial dysfunction, vascular aging, and oxidative stresses have been shown to cause thrombotic events and platelet excitability in humans, which in turn induce atherosclerosis [69, 72]

RESULTS Base Case Analysis (2 Retreatments) In the base-case analysis with 2 retreatments, semaglutide 2.4 mg plus D&E incurred higher lifetime costs but generated meaningful health gains compared with D&E alone

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