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The major COVID-19-associated metabolic risks (old age, hypertension, cardiovascular diseases, diabetes, and obesity) share high PAI-1 levels and could predispose certain groups to severe COVID-19 complications

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Regulated cell death apoptosis, in contrast, has different biochemical, functional and immunological effects and is carried out by a group of identified effector molecules (apoptosis, necroptosis, pyroptosis, oxeiptosis, ferroptosis, parthanatos) [36]

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5 , e1015 (2014)