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7 In pancreatic -cells, GLP-1R activation by semaglutide enhances glucose catabolism and insulin secretion via the mTOR-dependent HIF-1 pathway, facilitating glycolysis and insulin release
And 11.3 percent of high-dose participants quit the pivotal trial over side effects, about double the placebo rate
10.1212/WNL.57.2.245 35 CroenL
In addition, many questions remain about the long-term effectiveness and risks of these drugs as well as whether there are differences between GLP-1 formulations
Diabetes Care 42(6):991993
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