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Description

If Wnt suppression in AGA follicles results partly from elevated CXXC5, then reducing DHT (the approach of finasteride and dutasteride) addresses the problem upstream: less DHT means less CXXC5 induction, means less Wnt suppression

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The reason turned out to be metabolic: Akkermansia produces nicotinamide (vitamin B3) as a metabolite, and nicotinamide levels were low in the ALS mice (and in ALS patients) [215]

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