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For individuals in the UK seeking support with weight management today, options recommended within the NHS framework include: Lifestyle interventions as first-line management, supported through Tier 2 community weight management services Orlistat for eligible patients, available via GP prescription Semaglutide (Wegovy) MHRA-licensed for chronic weight management and recommended by NICE (TA875) for use within specialist Tier 3 weight management services for qualifying patients, subject to eligibility criteria including BMI thresholds and weight-related comorbidities
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2.5 Statistical analysis We applied 1:1 propensity score matching (PSM) using greedy nearest neighbor matching with a 0.1 caliper to balance baseline characteristics between the tirzepatide and control groups
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