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GPx isoenzymes are all antioxidant enzymes that reduce potentially damaging reactive oxygen species (ROS), such as hydrogen peroxide and lipid hydroperoxides, to harmless products like water and alcohols by coupling their reduction with the oxidation of glutathione (Figure 2a )

Additionally, N-Acetyl Cysteine (NAC), the precursor to GSH, when combined with RIF significantly lowered M

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Further, a clinical study has demonstrated that the combination of GLP-1R agonist and sodiumglucose cotransporter 2 (SGLT2) inhibitors significantly reduces the risk of all cause-mortality and improves renal function, compared to GLP-1R agonist alone in type 2 diabetic patients [69]