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Through the addition of a fatty acid side chain, an acidic gamma-Glu group, and lipophilic 2xOEG groups, the molecule can bind more securely to plasma albumin, thereby reducing its glomerular ltration rate4

Significant comorbidity exists among these conditions, exemplified by the frequent co-occurrence of depression and ASD with epilepsy (277), the common comorbidity of depression with migraine (277), and the elevated prevalence of inflammatory bowel disease or irritable bowel syndrome among migraine patients (278)

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