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Since the initial FDA warning in 2013, more studies have come out that dont show an increase in pancreatic cancer

Scientists have found links between the gut microbiome bacteria colonies in the gut and these conditions

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Part of the GLP1 agonists mechanism of action is slowing the stomach propulsion of its contents, and in turn, this allows some pills to have more time to get absorbed, leading to higher drug levels of meds like thyroid hormone

All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)