The red arrows in Figure 1 show what we call long-range interactions, in which substrates allosterically affect distant enzymes in the network
Also, while the manufacturers of metformin recommend against breastfeeding while taking the drug, data have shown that metformin is excreted into breast milk in small amounts and adverse effects on infant plasma glucose have not been reported in human studies
Feldman H, Sepesi B, Leung CH, Lin H, Weissferdt A, Pataer A, William WN Jr, Walsh GL, Rice DC, Roth JA, Mehran RJ, Hofstetter WL, Antonoff MB, Rajaram R, Gibbons DL, Lee JJ, Heymach JV, Vaporciyan AA, Swisher SG , Cascone T
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10.1073/pnas.1113306109 59 HuK