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A significant decrease in plasma Hcy was observed for the DCr (75 (sd 12) mol/l) and CrO+D (72 (sd 17) mol/l) groups compared with the control group (124 (sd 22) mol/l)

In preclinical and clinical research models, this has translated into effects on energy expenditure, hepatic lipid metabolism, and body composition that go beyond what dual agonists alone have demonstrated

While thorough questionnaires can identify most contraindications and risk factors, the lack of physical examination may miss subtle signs of underlying conditions that could affect treatment safety or efficacy

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