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( Bmal1 (one of the essential clock genes that participate in the maintenance of the circadian periodicity at the cellular level) in mice suprachiasmatic nucleus (SCN) led to increased escape latencies and number of escape failures in the learned helplessness paradigm, induced higher immobility time in the tail suspension test, and decreased the time spent in the light compartment of the light/dark test

Histopathological examination using H&E and AB-PAS staining revealed severe pathological changes in the colonic epithelium of DSS-treated mice

This pattern reflects the time required for tissue repair processes to manifest as functional improvements

By blocking NNMT, 5-Amino-1MQ drives several metabolic benefits: Boosts NAD Levels Inhibiting NNMT preserves more nicotinamide for NAD synthesis, leading to enhanced mitochondrial function, increased cellular energy output, and activation of sirtuins , the proteins involved in longevity and DNA repair

doi: 10.1111/febs.17333 151 Kullak-UblickGAStiegerBMeierPJ