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This can range from the formation of painful gallstones to severe inflammation (cholecystitis) that often necessitates surgical removal of the gallbladder (cholecystectomy)

A successful pH-sensitive mutant would exhibit a K_D comparable to the wild-type antibody at neutral pH to ensure cell surface binding, but a significantly weakened K_D (markedly increased k_off rate) at acidic pH to facilitate rapid dissociation in the lysosome and enable efficient receptor recycling [76]

doi:10.3390/ph18020185

Management Tips To reduce the risk of hypoglycemia, healthcare providers often recommend lowering the sulfonylurea dose when starting GLP-1 therapy

Oxidation hits susceptible amino acids like methionine, cysteine, and tryptophan