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The results, which were published in the Lancet on Thursday, are very encouraging for the safety and efficacy of orforglipron in people with type 2 diabetes, says Daniel Drucker, an endocrinologist at the University of Toronto, adding that he is awaiting further clinical trial results of the drug in people with obesity
In several studies, GLP-1RA have been proved to reduce glucose levels, to ameliorate the metabolic syndrome and to provide cardiorenal benefits [2,3,4,5]
The control of ROS levels in cells is crucial for cellular homeostasis, as Moderate ROS levels in cells can serve as signaling molecules, but excessive ROS production can lead to damage to DNA, proteins, and lipids [2]
Durable efficacy of liraglutide in patients with type 2 diabetes and pronounced insulin-associated weight gain: 52-week results from the effect of liraglutide on insulin-associated weight gain in patients with type 2 diabetes (ELEGANT) randomized controlled trial