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One to Two Weeks: Continued improvements in energy stability, cognitive performance, and mood often become apparent, with many patients reporting better sleep quality and morning alertness

For people with cobalt allergy (which is more common among people with nickel allergy) who are also at risk of vitamin B12 deficiency, the "general advice seems to be 'take just enough but not too much,' which isn't too different from dosing advice for all vitamins and drugs" (via ACSH)

Whilst extremely rare, anaphylaxis to B12 preparations has been documented

Researchers should add one compound at a time, assess tolerance, and avoid the temptation to implement complex protocols immediately

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