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This article summarizes the current clinical study program and the respective outcomes and highlights further potential indications for tirzepatide in the treatment of obesity and potentially other comorbidities of T2D

Semaglutide works by: Enhancing insulin secretion in a glucose-dependent manner, which helps regulate blood sugar levels Suppressing glucagon release , reducing hepatic glucose output Slowing gastric emptying , which prolongs satiety and reduces appetite Acting on appetite centres in the brain , particularly the hypothalamus, to reduce hunger and food intake These combined effects led to significant weight loss in clinical trials (STEP programme), typically in the range of 1015% of body weight over 68 weeks, though individual results vary considerably

The use of naltrexone/bupropion led to decreased waist circumference

(5) People who took at least 4 mg of retatrutide lost about 20-25% of their body weight

However, there are few reports of serious side effects