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Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist
L- 8-12 , 4-6
The specific criteria for prescribing semaglutide include a BMI of 27 or higher with at least one weight-related condition, or a BMI of 30 or higher
Oxidative stress contributes to these conditions by damaging endothelial cells and impairing their function [187]
Jastreboff and colleagues studied the obesity Phase 2 in NEJM observing mean body weight reduction reaching approximately 24 percent at the 12 mg dose tier at 48 weeks (PMID 37366315)
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