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Case reports and safety reviews have linked Lcarnitine with new seizures or increased seizure frequency in some susceptible individuals

Together, these observations suggest that receptor-level signaling and anti-inflammatory effects alone may be insufficient to produce functional improvement in energy-demanding tissues such as skeletal muscle and brain, where substrate turnover and mitochondrial metabolic throughput are critical determinants of tissue function

[,] Vitamin D deficiency is commonly seen and even worsens during chronic kidney disease and its progression

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doi: 10.1016/j.phytochem.2006.02.024 4