Clinical dosing typically ranges from 5 to 30 milliliters daily for 10 to 20 day courses, administered by injection
Protocol: Dosing typically follows a titration schedule , starting at a low dose (e.g., 0.3 mg) and gradually escalating every four weeks until the target dose (2.4 mg) is achieved
To address the critical issue of BBB permeability, studies using [H]Dihexa and [C]inulin in rats revealed that Dihexa avidly concentrated in all examined brain regions including the prefrontal cortex, hippocampus, hypothalamus, striatum, thalamus, midbrain, brain stem, and cerebellum, compared to blood
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Lancet (2018) 392:2299312