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The study included adults with type 2 diabetes using #metformin (1500 mg/day) with glycated haemoglobin (HbA1c) concentrations between 70% and 105% (5391 mmol/mol), stable bodyweight (5%), and a BMI of 230 kg/m2 or more

Researchers continue to investigate how NNMT inhibition affects intracellular signaling, energy utilization, and the complex biochemical pathways involved in maintaining cellular homeostasis

PMID: 1700785

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(2015) trial showed that high-dose oral supplementation (1,000 mg/day) did increase blood glutathione levels over 6 months, but the effect was far smaller than parenteral routes