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Landmark cardiovascular outcome trials like LEADER and SELECT have demonstrated the cardiometabolic benefits of GLP1-RA in the reduction of MACE events in populations with T2DM as well as populations with overweight or obesity in the absence of T2DM

For a deeper discussion of the study design and findings, see our full GLP-1 receptor agonist feasibility study on linear vs fragment SPPS

And long-term use can have complications for some, like whats being called "Ozempic face." "So, what you tend to see is droopiness, or sagginess, or a really deflated look throughout the face from the temples, to the underlid, or tear trough area, through the cheek region, to the nasal and marionette lines, and the jaw, said Doctor Edward Davidson, a Cranial, Facial, & Cosmetic Plastic Surgeon with the Palm Beach Health Network

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European Food Safety Authority (EFSA) Panel on Dietetic Products, Nutrition and Allergies (NDA)