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By preventing inactivation of GLP-1, DPP-4i has been found to significantly improve -cell function and glycemic control, albeit its effects are attenuated in patients with high levels of insulin resistance [87, 88]

CT or MRI: Used when deeper tissue assessment is needed or if there is concern for more extensive disease

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As with other medicines in the incretin-based drug class, the most commonly reported side effects of retatrutide in clinical trials were gastrointestinal in nature (Jastreboff et al., 2023)