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[22] Some of these metabolic improvements may occur partly independently of weight loss, as suggested by mediation analyses from cardiovascular outcome trials, potentially reflecting effects on insulin sensitivity and vascular health that may be relevant for patients with obesity-related comorbidities like sleep apnea

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Additionally, 27% of GLP-1 users reported making healthier food choices

So are loci tied to energy expenditure and mitochondrial efficiency, FTO , MC4R , the UCP family, given that retatrutides mechanism explicitly leans on raising metabolic rate rather than just suppressing intake